Compound Detail
CHEMBL540084
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Basic Information
| ChEMBL ID | CHEMBL540084 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GNHBMWFAQHCGAP-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1190082 |
| Active Moiety | CHEMBL1190082 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
439.3
MW (Da)
2.98
ALogP
9
HBA
3
HBD
117.5
PSA (Ų)
0.50
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 9.47 | 9.47 | 0.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 0.34 | nM | 9.47 | Inhibition of [3H]MDL-105,519 binding to NMDA receptor glycine-binding site | 9871631 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9871631 | 10.1016/s0960-894x(97)10187-1 | Glutamate receptor ionotropic, AMPA | 1 |
| 9871631 | 10.1016/s0960-894x(97)10187-1 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine