Assay Detail
Binding
CHEMBL749367
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]MDL-105,519 binding to NMDA receptor glycine-binding site
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.89 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540084 | — | — | 1 | 9.47 |
| CHEMBL163000 | — | — | 1 | 7.52 |
| CHEMBL162757 | — | — | 1 | 7.30 |
| CHEMBL349778 | — | — | 1 | 6.92 |
| CHEMBL552793 | — | — | 1 | 6.92 |
| CHEMBL556379 | — | — | 1 | 6.39 |
| CHEMBL553402 | — | — | 1 | 6.30 |
| CHEMBL544884 | — | — | 1 | 6.14 |
| CHEMBL162066 | — | — | 1 | 6.12 |
| CHEMBL536244 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540084 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL163000 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL162757 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL349778 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL552793 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL556379 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL553402 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL544884 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL162066 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL536244 | — | IC50 | = | 1400.0 | nM | 5.85 |