Assay Detail
Binding
CHEMBL748567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability of compound to compete with [3H]glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampus
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and molecular modeling of 3-acylamino-2- Carboxyindole NMDA receptor glycine-site antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.21 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300949 | — | — | 1 | 7.00 |
| CHEMBL132501 | — | — | 1 | 6.96 |
| CHEMBL50267 | — | — | 1 | 6.85 |
| CHEMBL143897 | — | — | 1 | 6.77 |
| CHEMBL141284 | — | — | 1 | 6.57 |
| CHEMBL341813 | — | — | 1 | 6.40 |
| CHEMBL141754 | — | — | 1 | 5.52 |
| CHEMBL357294 | — | — | 1 | 5.02 |
| CHEMBL143325 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300949 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL132501 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL50267 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL143897 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL141284 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL341813 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL141754 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL357294 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL143325 | — | IC50 | = | 17000.0 | nM | 4.77 |