Compound Detail
CHEMBL771
CYCLOSERINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL771 |
| Name | CYCLOSERINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | DYDCUQKUCUHJBH-UWTATZPHSA-N |
| Therapeutic | ✓ Yes |
5
Targets
24
Activities
3
Assay Types
0
PK Parameters
20
Publications
8
Known Names
20
Indications
2
Mechanisms
Molecular Properties
102.1
MW (Da)
-1.62
ALogP
3
HBA
2
HBD
64.3
PSA (Ų)
0.39
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1964 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| D-alanylalanine synthetase inhibitor | INHIBITOR | D-alanine--D-alanine ligase | ✓ | ✓ |
| Alanine racemase inhibitor | INHIBITOR | Alanine racemase | ✓ | ✓ |
Indications
Tuberculosis Tuberculosis Asperger Syndrome Autistic Disorder Obsessive-Compulsive Disorder Pain Panic Disorder Phobia, Social Phobic Disorders Schizophrenia Smoking Cessation Stress Disorders, Post-Traumatic Tuberculosis, Pulmonary Agoraphobia Alcohol Drinking Bipolar Disorder Brain Injuries Cocaine-Related Disorders Depressive Disorder, Major Fibromyalgia
ATC Classification
J04AB01
cycloserine
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIMYCOBACTERIALS
Activity Summary
IC50 13 meas. best 5.64
EC50 6 meas. best 5.53
Ki 5 meas. best 4.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | EC50 | 5.53 | 5.53 | 2950.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.2 | 5.2 | 6309.6 | 1 |
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | IC50 | 5.13 | 5.13 | 7370.0 | 1 |
| Mycobacterium tuberculosis CHEMBL360 | EC50 | 4.9 | 4.7133 | 12470.0 | 3 |
| Mycobacterium tuberculosis CHEMBL360 | IC50 | 4.9 | 4.8267 | 12470.0 | 6 |
| Glutamate receptor ionotropic, NMDA 2C CHEMBL401 | EC50 | 4.74 | 4.74 | 18100.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 4.66 | 4.61 | 22000.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine