Assay Detail
Binding
CHEMBL952311
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Inhibition of Escherichia coli DdlB
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of new inhibitors of D-alanine:D-alanine ligase by structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.81 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463588 | — | — | 1 | 5.40 |
| CHEMBL456667 | — | — | 1 | 5.40 |
| CHEMBL363332 | — | — | 1 | 4.96 |
| CHEMBL458117 | — | — | 1 | 4.90 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 1 | 4.66 |
| CHEMBL513114 | — | — | 1 | 4.48 |
| CHEMBL500374 | — | — | 1 | 4.38 |
| CHEMBL57369 | — | — | 1 | 4.30 |
| CHEMBL228043 | — | — | 1 | - |
| CHEMBL463783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463588 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL456667 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL363332 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL458117 | — | Ki | = | 12500.0 | nM | 4.90 |
| CHEMBL771 | CYCLOSERINE | Ki | = | 22000.0 | nM | 4.66 |
| CHEMBL513114 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL500374 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL57369 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL228043 | — | Ki | = | 185000.0 | nM | - |
| CHEMBL463783 | — | Ki | = | 218000.0 | nM | - |