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Assay Detail

CHEMBL2344964

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Functional
Antitubercular activity against Mycobacterium tuberculosis H37Rv by microdilution alamar Blue broth assay
ChEMBL ↗
45
Total Activities
20
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycobacterium tuberculosis (CHEMBL360) ↗
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly functionalised dispiropyrrolidines acting as antimycobacterial agents.
Wei AC, Ali MA, Yoon YK, Ismail R, Choon TS, Kumar RS.
Bioorg Med Chem Lett (2013) 23 : 1383 -1386
PubMed 23352268 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC90 20 - -
EC50 20 4.96 7.70
MIC 5 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL374478 RIFAMPIN 4.0 3 7.70
CHEMBL177 AMIKACIN 4.0 3 6.92
CHEMBL64 ISONIAZID 4.0 2 6.72
CHEMBL44884 ETHAMBUTOL 4.0 2 5.46
CHEMBL2331869 — — 2 4.82
CHEMBL2331856 — — 2 4.63
CHEMBL771 CYCLOSERINE 4.0 3 4.61
CHEMBL36 PYRIMETHAMINE 4.0 3 4.60
CHEMBL2331857 — — 2 4.44
CHEMBL2331861 — — 2 4.39
CHEMBL2331863 — — 2 4.25
CHEMBL2331862 — — 2 4.20
CHEMBL2331865 — — 2 4.17
CHEMBL2331868 — — 2 4.17
CHEMBL2331859 — — 3 4.16
CHEMBL2331860 — — 2 4.11
CHEMBL2331864 — — 2 -
CHEMBL2331858 — — 2 -
CHEMBL2331866 — — 2 -
CHEMBL2331867 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL374478 RIFAMPIN EC50 = 20.0 nM 7.70
CHEMBL177 AMIKACIN EC50 = 120.0 nM 6.92
CHEMBL64 ISONIAZID EC50 = 190.0 nM 6.72
CHEMBL44884 ETHAMBUTOL EC50 = 3450.0 nM 5.46
CHEMBL2331869 — EC50 = 15070.0 nM 4.82
CHEMBL2331856 — EC50 = 23430.0 nM 4.63
CHEMBL771 CYCLOSERINE EC50 = 24760.0 nM 4.61
CHEMBL36 PYRIMETHAMINE EC50 = 25090.0 nM 4.60
CHEMBL2331857 — EC50 = 36600.0 nM 4.44
CHEMBL2331861 — EC50 = 40900.0 nM 4.39
CHEMBL2331863 — EC50 = 55990.0 nM 4.25
CHEMBL2331862 — EC50 = 63840.0 nM 4.20
CHEMBL2331865 — EC50 = 67960.0 nM 4.17
CHEMBL2331868 — EC50 = 68460.0 nM 4.17
CHEMBL2331859 — EC50 = 69210.0 nM 4.16
CHEMBL2331860 — EC50 = 77500.0 nM 4.11
CHEMBL2331856 — EC90 > 100.0 uM -
CHEMBL2331857 — EC90 > 100.0 uM -
CHEMBL2331858 — EC90 > 100.0 uM -
CHEMBL2331859 — EC90 = 99.7 uM -
CHEMBL2331860 — EC90 > 100.0 uM -
CHEMBL2331861 — EC90 > 100.0 uM -
CHEMBL2331862 — EC90 > 100.0 uM -
CHEMBL2331863 — EC90 > 100.0 uM -
CHEMBL2331864 — EC90 > 100.0 uM -
CHEMBL2331865 — EC90 > 100.0 uM -
CHEMBL36 PYRIMETHAMINE MIC = 100000.0 nM -
CHEMBL771 CYCLOSERINE EC90 = 28.01 uM -
CHEMBL64 ISONIAZID EC90 > 5.0 uM -
CHEMBL374478 RIFAMPIN EC90 = 0.02 uM -
CHEMBL177 AMIKACIN EC90 = 0.14 uM -
CHEMBL36 PYRIMETHAMINE EC90 = 28.0 uM -
CHEMBL44884 ETHAMBUTOL EC90 > 200.0 uM -
CHEMBL2331859 — MIC = 100000.0 nM -
CHEMBL771 CYCLOSERINE MIC = 100000.0 nM -
CHEMBL374478 RIFAMPIN MIC = 160.0 nM -
CHEMBL177 AMIKACIN MIC = 160.0 nM -
CHEMBL2331866 — EC90 > 100.0 uM -
CHEMBL2331867 — EC50 > 100000.0 nM -
CHEMBL2331858 — EC50 > 100000.0 nM -
CHEMBL2331864 — EC50 > 100000.0 nM -
CHEMBL2331866 — EC50 > 100000.0 nM -
CHEMBL2331869 — EC90 > 100.0 uM -
CHEMBL2331867 — EC90 > 100.0 uM -
CHEMBL2331868 — EC90 > 100.0 uM -