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Compound Detail

CHEMBL2331869

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CN1C[C@H](c2ccc(Br)cc2)[C@]2(Cc3ccccc3C2=O)[C@]12C(=O)c1cccc3cccc2c13

Basic Information

ChEMBL ID CHEMBL2331869
Phase Preclinical
Structure Type MOL
InChI Key RDEMHYKOMLLOPQ-CPESWEKQSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

508.4
MW (Da)
6.15
ALogP
3
HBA
0
HBD
37.4
PSA (Ų)
0.31
QED
2
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H22BrNO2
MW 508.42
Aromatic Rings 4
Heavy Atoms 34
NP-Likeness 0.22

Activity Summary

EC50 2 meas. best 5.66

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycobacterium tuberculosis
CHEMBL360
EC50 5.66 5.24 2200.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23352268 10.1016/j.bmcl.2012.12.069 Mycobacterium tuberculosis 11
23352268 10.1016/j.bmcl.2012.12.069 Vero 1

Data from ChEMBL 36 via Core Engine