Assay Detail
Functional
CHEMBL3796292
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 incubated for 7 days by BacTiter-Glo cell viability assay
85
Total Activities
30
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Cell Type | BacTiter-Glo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.58 | 7.70 |
| IC90 | 30 | - | - |
| MIC | 25 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 3 | 7.70 |
| CHEMBL64 | ISONIAZID | 4.0 | 3 | 7.00 |
| CHEMBL177 | AMIKACIN | 4.0 | 3 | 6.99 |
| CHEMBL3792525 | — | — | 3 | 6.30 |
| CHEMBL3754495 | — | — | 3 | 6.00 |
| CHEMBL44884 | ETHAMBUTOL | 4.0 | 3 | 5.92 |
| CHEMBL3793410 | — | — | 3 | 5.92 |
| CHEMBL3793426 | — | — | 3 | 5.89 |
| CHEMBL3792754 | — | — | 3 | 5.82 |
| CHEMBL3753581 | — | — | 3 | 5.66 |
| CHEMBL3752490 | — | — | 3 | 5.51 |
| CHEMBL3752821 | — | — | 3 | 5.44 |
| CHEMBL3752067 | — | — | 3 | 5.43 |
| CHEMBL3752880 | — | — | 3 | 5.40 |
| CHEMBL3751862 | — | — | 3 | 5.28 |
| CHEMBL3754715 | — | — | 3 | 5.27 |
| CHEMBL497740 | — | — | 3 | 5.24 |
| CHEMBL3794154 | — | — | 3 | 5.14 |
| CHEMBL3794043 | — | — | 3 | 5.14 |
| CHEMBL3794108 | — | — | 3 | 5.08 |
| CHEMBL3794183 | — | — | 3 | 4.87 |
| CHEMBL3794388 | — | — | 3 | 4.76 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 3 | 4.68 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 3 | 4.63 |
| CHEMBL3793400 | — | — | 3 | 4.53 |
| CHEMBL3793158 | — | — | 2 | - |
| CHEMBL3793237 | — | — | 2 | - |
| CHEMBL3793655 | — | — | 2 | - |
| CHEMBL3753686 | — | — | 2 | - |
| CHEMBL3752598 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL64 | ISONIAZID | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL177 | AMIKACIN | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL3792525 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3754495 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3793410 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL44884 | ETHAMBUTOL | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3793426 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3792754 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL3753581 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL3752490 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL3752821 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3752067 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL3752880 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3751862 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3754715 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL497740 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL3794154 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL3794043 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3794108 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3794183 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL3794388 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL771 | CYCLOSERINE | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 23600.0 | nM | 4.63 |
| CHEMBL3793400 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL3752067 | — | MIC | = | 6200.0 | nM | - |
| CHEMBL3793426 | — | MIC | = | 3100.0 | nM | - |
| CHEMBL3752821 | — | MIC | = | 6200.0 | nM | - |
| CHEMBL3752490 | — | MIC | = | 6200.0 | nM | - |
| CHEMBL3751862 | — | MIC | = | 12500.0 | nM | - |
| CHEMBL3793410 | — | MIC | = | 3100.0 | nM | - |
| CHEMBL3754715 | — | MIC | = | 12500.0 | nM | - |
| CHEMBL3754495 | — | MIC | = | 1600.0 | nM | - |
| CHEMBL3753581 | — | MIC | = | 6200.0 | nM | - |
| CHEMBL3752880 | — | MIC | = | 12500.0 | nM | - |
| CHEMBL3792525 | — | MIC | = | 1600.0 | nM | - |
| CHEMBL3794108 | — | MIC | = | 25000.0 | nM | - |
| CHEMBL3794043 | — | MIC | = | 25000.0 | nM | - |
| CHEMBL3794183 | — | MIC | = | 25000.0 | nM | - |
| CHEMBL3793400 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL3794388 | — | MIC | = | 25000.0 | nM | - |
| CHEMBL3792754 | — | MIC | = | 3100.0 | nM | - |
| CHEMBL3794154 | — | MIC | = | 25000.0 | nM | - |
| CHEMBL497740 | — | MIC | = | 12500.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | IC90 | = | 30.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | IC90 | = | 36000.0 | nM | - |
| CHEMBL64 | ISONIAZID | IC90 | = | 200.0 | nM | - |
| CHEMBL771 | CYCLOSERINE | IC90 | = | 33100.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | MIC | = | 40.0 | nM | - |
| CHEMBL44884 | ETHAMBUTOL | IC90 | = | 1800.0 | nM | - |