Assay Detail
Functional
CHEMBL4022472
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Antimicrobial activity against Mycobacterium tuberculosis H37Rv by Alamar blue assay
57
Total Activities
19
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
One-pot microwave assisted stereoselective synthesis of novel dihydro-2'H-spiro[indene-2,1'-pyrrolo-[3,4-c]pyrrole]-tetraones and evaluation of their antimycobacterial activity and inhibition of AChE.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 19 | - | - |
| IC90 | 19 | - | - |
| IC50 | 19 | 5.01 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177 | AMIKACIN | 4.0 | 3 | 7.16 |
| CHEMBL64 | ISONIAZID | 4.0 | 3 | 6.75 |
| CHEMBL4098808 | — | — | 3 | 5.89 |
| CHEMBL4071803 | — | — | 3 | 5.66 |
| CHEMBL4097877 | — | — | 3 | 4.96 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 3 | 4.90 |
| CHEMBL4079853 | — | — | 3 | 4.88 |
| CHEMBL4089033 | — | — | 3 | 4.80 |
| CHEMBL4072825 | — | — | 3 | 4.76 |
| CHEMBL4069096 | — | — | 3 | 4.66 |
| CHEMBL4088091 | — | — | 3 | 4.64 |
| CHEMBL4066805 | — | — | 3 | 4.55 |
| CHEMBL4093532 | — | — | 3 | 4.55 |
| CHEMBL4080216 | — | — | 3 | 4.54 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 3 | 4.43 |
| CHEMBL4090159 | — | — | 3 | 4.40 |
| CHEMBL4104459 | — | — | 3 | 4.33 |
| CHEMBL4060832 | — | — | 3 | 4.26 |
| CHEMBL44884 | ETHAMBUTOL | 4.0 | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177 | AMIKACIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL64 | ISONIAZID | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4098808 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4071803 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL4097877 | — | IC50 | = | 11070.0 | nM | 4.96 |
| CHEMBL771 | CYCLOSERINE | IC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL4079853 | — | IC50 | = | 13190.0 | nM | 4.88 |
| CHEMBL4089033 | — | IC50 | = | 15870.0 | nM | 4.80 |
| CHEMBL4072825 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL4069096 | — | IC50 | = | 21910.0 | nM | 4.66 |
| CHEMBL4088091 | — | IC50 | = | 22870.0 | nM | 4.64 |
| CHEMBL4093532 | — | IC50 | = | 28460.0 | nM | 4.55 |
| CHEMBL4066805 | — | IC50 | = | 28280.0 | nM | 4.55 |
| CHEMBL4080216 | — | IC50 | = | 28570.0 | nM | 4.54 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 37350.0 | nM | 4.43 |
| CHEMBL4090159 | — | IC50 | = | 39950.0 | nM | 4.40 |
| CHEMBL4104459 | — | IC50 | = | 47200.0 | nM | 4.33 |
| CHEMBL4060832 | — | IC50 | = | 54950.0 | nM | 4.26 |
| CHEMBL64 | ISONIAZID | IC90 | = | 290.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | IC90 | = | 74960.0 | nM | - |
| CHEMBL4071803 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL4098808 | — | MIC | = | 25000.0 | nM | - |
| CHEMBL4097877 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL4079853 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | MIC | = | 100000.0 | nM | - |
| CHEMBL4069096 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL4093532 | — | MIC | = | 100000.0 | nM | - |
| CHEMBL4072825 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL4104459 | — | MIC | = | 100000.0 | nM | - |
| CHEMBL4080216 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL4066805 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL4088091 | — | MIC | = | 50000.0 | nM | - |
| CHEMBL4089033 | — | MIC | = | 100000.0 | nM | - |
| CHEMBL4060832 | — | MIC | = | 100000.0 | nM | - |
| CHEMBL177 | AMIKACIN | MIC | = | 160.0 | nM | - |
| CHEMBL771 | CYCLOSERINE | MIC | = | 25000.0 | nM | - |
| CHEMBL44884 | ETHAMBUTOL | MIC | = | 12500.0 | nM | - |
| CHEMBL64 | ISONIAZID | MIC | = | 310.0 | nM | - |
| CHEMBL4090159 | — | MIC | = | 100000.0 | nM | - |
| CHEMBL4104459 | — | IC90 | = | 66500.0 | nM | - |
| CHEMBL4072825 | — | IC90 | = | 35500.0 | nM | - |
| CHEMBL4093532 | — | IC90 | = | 52420.0 | nM | - |
| CHEMBL4069096 | — | IC90 | = | 47930.0 | nM | - |
| CHEMBL4090159 | — | IC90 | = | 71870.0 | nM | - |
| CHEMBL4079853 | — | IC90 | = | 25900.0 | nM | - |
| CHEMBL4097877 | — | IC90 | = | 21980.0 | nM | - |
| CHEMBL4098808 | — | IC90 | = | 5300.0 | nM | - |
| CHEMBL4071803 | — | IC90 | = | 7860.0 | nM | - |
| CHEMBL4080216 | — | IC90 | = | 47720.0 | nM | - |
| CHEMBL44884 | ETHAMBUTOL | IC50 | < | 1560.0 | nM | - |