Assay Detail
Functional
CHEMBL3122917
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Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by Alamar Blue staining-based broth microdilution assay
69
Total Activities
23
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimycobacterial evaluation of novel hybrid arylidene thiazolidine-2,4-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC90 | 23 | - | - |
| EC90 | 23 | - | - |
| EC50 | 23 | 5.05 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177 | AMIKACIN | 4.0 | 3 | 7.16 |
| CHEMBL64 | ISONIAZID | 4.0 | 3 | 6.75 |
| CHEMBL3120382 | — | — | 3 | 5.22 |
| CHEMBL3120377 | — | — | 3 | 5.22 |
| CHEMBL3120372 | — | — | 3 | 5.10 |
| CHEMBL3120381 | — | — | 3 | 5.05 |
| CHEMBL3120386 | — | — | 3 | 5.00 |
| CHEMBL3120385 | — | — | 3 | 4.96 |
| CHEMBL3120387 | — | — | 3 | 4.96 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 3 | 4.90 |
| CHEMBL3120373 | — | — | 3 | 4.89 |
| CHEMBL3120380 | — | — | 3 | 4.85 |
| CHEMBL3120375 | — | — | 3 | 4.82 |
| CHEMBL3120388 | — | — | 3 | 4.80 |
| CHEMBL3120383 | — | — | 3 | 4.77 |
| CHEMBL3120378 | — | — | 3 | 4.75 |
| CHEMBL3120379 | — | — | 3 | 4.75 |
| CHEMBL3120374 | — | — | 3 | 4.72 |
| CHEMBL3120389 | — | — | 3 | 4.68 |
| CHEMBL3120376 | — | — | 3 | 4.62 |
| CHEMBL3120384 | — | — | 3 | 4.60 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 3 | 4.43 |
| CHEMBL44884 | ETHAMBUTOL | 4.0 | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177 | AMIKACIN | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL64 | ISONIAZID | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3120377 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3120382 | — | EC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3120372 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3120381 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3120386 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3120385 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3120387 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL771 | CYCLOSERINE | EC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL3120373 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3120380 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3120375 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3120388 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3120383 | — | EC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3120378 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3120379 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3120374 | — | EC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL3120389 | — | EC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL3120376 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3120384 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL36 | PYRIMETHAMINE | EC50 | = | 37350.0 | nM | 4.43 |
| CHEMBL3120389 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120372 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120373 | — | MIC90 | = | 50000.0 | nM | - |
| CHEMBL3120374 | — | MIC90 | = | 50000.0 | nM | - |
| CHEMBL3120375 | — | MIC90 | = | 50000.0 | nM | - |
| CHEMBL3120376 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120377 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120378 | — | MIC90 | = | 50000.0 | nM | - |
| CHEMBL3120388 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120380 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120381 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120382 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL177 | AMIKACIN | MIC90 | = | 160.0 | nM | - |
| CHEMBL771 | CYCLOSERINE | MIC90 | = | 25000.0 | nM | - |
| CHEMBL3120379 | — | MIC90 | = | 25000.0 | nM | - |
| CHEMBL44884 | ETHAMBUTOL | EC50 | < | 1560.0 | nM | - |
| CHEMBL3120376 | — | EC90 | = | 36.0 | uM | - |
| CHEMBL3120383 | — | EC90 | = | 36.0 | uM | - |
| CHEMBL3120384 | — | EC90 | = | 55.0 | uM | - |
| CHEMBL3120385 | — | EC90 | = | 25.0 | uM | - |
| CHEMBL3120386 | — | EC90 | = | 19.0 | uM | - |
| CHEMBL3120387 | — | EC90 | = | 27.0 | uM | - |
| CHEMBL3120388 | — | EC90 | = | 25.0 | uM | - |
| CHEMBL3120389 | — | EC90 | = | 55.0 | uM | - |
| CHEMBL3120372 | — | EC90 | = | 16.0 | uM | - |
| CHEMBL3120373 | — | EC90 | = | 27.0 | uM | - |
| CHEMBL3120374 | — | EC90 | = | 53.0 | uM | - |
| CHEMBL3120375 | — | EC90 | = | 54.0 | uM | - |