Assay Detail
Binding
CHEMBL749211
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In vitro inhibitory activity to inhibit [3H]glycine binding to NMDA receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.14 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL773 | GLYCINE | 4.0 | 1 | 6.60 |
| CHEMBL285123 | (D)-SERINE | 3.0 | 1 | 6.17 |
| CHEMBL283819 | — | — | 1 | 5.73 |
| CHEMBL286024 | — | — | 1 | 5.17 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 1 | 5.13 |
| CHEMBL30853 | — | — | 1 | 4.11 |
| CHEMBL29830 | — | — | 1 | 4.11 |
| CHEMBL31250 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL773 | GLYCINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL285123 | (D)-SERINE | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL283819 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL286024 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL771 | CYCLOSERINE | IC50 | = | 7370.0 | nM | 5.13 |
| CHEMBL30853 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL29830 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL31250 | — | IC50 | = | 83000.0 | nM | 4.08 |