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Assay Detail

CHEMBL5330457

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of C-terminal hexahistidine-tagged recombinant Staphylococcus aureus Ddl expressed in Escherichia coli BL21(DE3) using D-Ala as substrate in presence of ATP by PK/LDH couples assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Staphylococcus aureus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Structure-guided design and synthesis of ATP-competitive N-acyl-substituted sulfamide d-alanine-d-alanine ligase inhibitors.
Becker R, Pederick JL, Dawes EG, Bruning JB, Abell AD.
Bioorg Med Chem (2023) 96 : 117509 -117509
PubMed 37948922 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 4.00 4.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL771 CYCLOSERINE 4.0 1 4.00
CHEMBL5417368 1 -
CHEMBL5402032 1 -
CHEMBL5440745 1 -
CHEMBL5424165 1 -
CHEMBL5396815 1 -
CHEMBL5407206 1 -
CHEMBL5402555 1 -
CHEMBL5420631 1 -
CHEMBL5436716 1 -
CHEMBL5418871 1 -
CHEMBL5438962 1 -
CHEMBL5401403 1 -
CHEMBL5410966 1 -
CHEMBL5435848 1 -
CHEMBL5426157 1 -
CHEMBL5426136 1 -
CHEMBL5419717 1 -
CHEMBL5417102 1 -
CHEMBL5421362 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL771 CYCLOSERINE IC50 = 100000.0 nM 4.00
CHEMBL5417368 IC50 - -
CHEMBL5402032 IC50 = 2200000.0 nM -
CHEMBL5440745 IC50 - -
CHEMBL5424165 IC50 = 1600000.0 nM -
CHEMBL5396815 IC50 - -
CHEMBL5407206 IC50 - -
CHEMBL5402555 IC50 - -
CHEMBL5420631 IC50 - -
CHEMBL5436716 IC50 > 2500000.0 nM -
CHEMBL5418871 IC50 - -
CHEMBL5438962 IC50 - -
CHEMBL5401403 IC50 > 2500000.0 nM -
CHEMBL5410966 IC50 - -
CHEMBL5435848 IC50 - -
CHEMBL5426157 IC50 - -
CHEMBL5426136 IC50 = 1700000.0 nM -
CHEMBL5419717 IC50 - -
CHEMBL5417102 IC50 > 2500000.0 nM -
CHEMBL5421362 IC50 - -