Assay Detail
Functional
CHEMBL3119863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimicrobial activity against Mycobacterium tuberculosis H37Rv after 7 days by BacTiter-Glo assay
36
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of acridine and fused-quinoline derivatives as potential anti-tuberculosis agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC90 | 18 | - | - |
| IC50 | 18 | 5.56 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 2 | 7.70 |
| CHEMBL177 | AMIKACIN | 4.0 | 2 | 7.16 |
| CHEMBL64 | ISONIAZID | 4.0 | 2 | 6.75 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 2 | 5.30 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 2 | 4.90 |
| CHEMBL3115424 | — | — | 2 | 4.35 |
| CHEMBL3115425 | — | — | 2 | 4.21 |
| CHEMBL3115421 | — | — | 2 | 4.13 |
| CHEMBL3115418 | — | — | 2 | - |
| CHEMBL3115419 | — | — | 2 | - |
| CHEMBL3115420 | — | — | 2 | - |
| CHEMBL3112618 | — | — | 2 | - |
| CHEMBL3115422 | — | — | 2 | - |
| CHEMBL3115423 | — | — | 2 | - |
| CHEMBL44884 | ETHAMBUTOL | 4.0 | 2 | - |
| CHEMBL3115594 | — | — | 2 | - |
| CHEMBL3115592 | — | — | 2 | - |
| CHEMBL3115593 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL177 | AMIKACIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL64 | ISONIAZID | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL771 | CYCLOSERINE | IC50 | = | 12470.0 | nM | 4.90 |
| CHEMBL3115424 | — | IC50 | = | 44350.0 | nM | 4.35 |
| CHEMBL3115425 | — | IC50 | = | 61930.0 | nM | 4.21 |
| CHEMBL3115421 | — | IC50 | = | 73410.0 | nM | 4.13 |
| CHEMBL44884 | ETHAMBUTOL | IC90 | = | 32790.0 | nM | - |
| CHEMBL3115419 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL771 | CYCLOSERINE | IC90 | = | 13490.0 | nM | - |
| CHEMBL177 | AMIKACIN | IC90 | = | 80.0 | nM | - |
| CHEMBL3115594 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115593 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115592 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115418 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115424 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115423 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115422 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3112618 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115421 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL3115420 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL64 | ISONIAZID | IC90 | = | 290.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | IC90 | = | 5000.0 | nM | - |
| CHEMBL3115425 | — | IC90 | = | 95410.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | IC90 | = | 20.0 | nM | - |
| CHEMBL3115419 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115420 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44884 | ETHAMBUTOL | IC50 | < | 1560.0 | nM | - |
| CHEMBL3112618 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115594 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115593 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115592 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115418 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115422 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3115423 | — | IC50 | > | 100000.0 | nM | - |