Assay Detail
Functional
CHEMBL4252975
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Antimycobacterial activity against Mycobacterium tuberculosis H37Rv
94
Total Activities
32
Compounds Tested
4
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mycobacterium tuberculosis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| MIC | 31 | - | - |
| IC50 | 31 | 5.25 | 7.70 |
| IC90 | 31 | - | - |
| MIC99 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | 4.0 | 3 | 7.70 |
| CHEMBL177 | AMIKACIN | 4.0 | 3 | 7.10 |
| CHEMBL64 | ISONIAZID | 4.0 | 3 | 6.92 |
| CHEMBL44884 | ETHAMBUTOL | 4.0 | 3 | 5.90 |
| CHEMBL4283055 | — | — | 3 | 5.75 |
| CHEMBL4289635 | — | — | 3 | 5.42 |
| CHEMBL4288358 | — | — | 3 | 5.42 |
| CHEMBL4286207 | — | — | 3 | 5.34 |
| CHEMBL4285188 | — | — | 3 | 5.31 |
| CHEMBL4278300 | — | — | 3 | 5.24 |
| CHEMBL4288755 | — | — | 3 | 5.17 |
| CHEMBL4280456 | — | — | 3 | 5.10 |
| CHEMBL4278276 | — | — | 3 | 4.96 |
| CHEMBL4281761 | — | — | 3 | 4.96 |
| CHEMBL4293429 | — | — | 3 | 4.75 |
| CHEMBL4277027 | — | — | 3 | 4.69 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 3 | 4.68 |
| CHEMBL4294516 | — | — | 3 | 4.64 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 3 | 4.63 |
| CHEMBL4286608 | — | — | 3 | 4.40 |
| CHEMBL4282819 | — | — | 3 | 4.37 |
| CHEMBL4288961 | — | — | 3 | 4.27 |
| CHEMBL4284982 | — | — | 3 | 4.04 |
| CHEMBL4283388 | — | — | 3 | - |
| CHEMBL4281008 | — | — | 3 | - |
| CHEMBL4278096 | — | — | 3 | - |
| CHEMBL4291234 | — | — | 3 | - |
| CHEMBL4293017 | — | — | 3 | - |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
| CHEMBL4293649 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374478 | RIFAMPIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL177 | AMIKACIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL64 | ISONIAZID | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL44884 | ETHAMBUTOL | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4283055 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4288358 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4289635 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4286207 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4285188 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4278300 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4288755 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4280456 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4278276 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4281761 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL4293429 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4277027 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL771 | CYCLOSERINE | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL4294516 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4286608 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4282819 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL4288961 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4284982 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL4283055 | — | IC90 | = | 2500.0 | nM | - |
| CHEMBL4293649 | — | IC90 | > | 100000.0 | nM | - |
| CHEMBL4288358 | — | IC90 | = | 5200.0 | nM | - |
| CHEMBL4280456 | — | IC90 | = | 12000.0 | nM | - |
| CHEMBL4284982 | — | IC90 | = | 110000.0 | nM | - |
| CHEMBL4292177 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL4281554 | — | IC90 | > | 200000.0 | nM | - |
| CHEMBL4292177 | — | IC90 | > | 200000.0 | nM | - |
| CHEMBL4278096 | — | IC90 | > | 200000.0 | nM | - |
| CHEMBL4288755 | — | IC90 | = | 7700.0 | nM | - |
| CHEMBL4294516 | — | IC90 | = | 27000.0 | nM | - |
| CHEMBL4286608 | — | IC90 | = | 70000.0 | nM | - |
| CHEMBL4286207 | — | IC90 | = | 14100.0 | nM | - |
| CHEMBL4278276 | — | IC90 | = | 53000.0 | nM | - |
| CHEMBL4288961 | — | IC90 | = | 97000.0 | nM | - |
| CHEMBL177 | AMIKACIN | IC90 | = | 90.0 | nM | - |
| CHEMBL771 | CYCLOSERINE | IC90 | = | 33100.0 | nM | - |
| CHEMBL44884 | ETHAMBUTOL | IC90 | = | 1780.0 | nM | - |
| CHEMBL64 | ISONIAZID | IC90 | = | 190.0 | nM | - |
| CHEMBL36 | PYRIMETHAMINE | IC90 | = | 35900.0 | nM | - |
| CHEMBL374478 | RIFAMPIN | IC90 | = | 30.0 | nM | - |
| CHEMBL4277027 | — | IC90 | = | 82500.0 | nM | - |
| CHEMBL4281761 | — | IC90 | = | 12400.0 | nM | - |
| CHEMBL4281008 | — | IC90 | - | — | - | |
| CHEMBL4283388 | — | IC90 | - | — | - | |
| CHEMBL4291234 | — | IC90 | - | — | - | |
| CHEMBL4289635 | — | IC90 | = | 11500.0 | nM | - |