Glutamate receptor ionotropic, NMDA 2C · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt Q00961. Use UniProt Q00961 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q00961 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, NMDA 2C
Review this target as Glutamate receptor ionotropic, NMDA 2C, mapped to UniProt Q00961. Sequence length is 1237 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor ionotropic, NMDA 2C as ChEMBL target CHEMBL401, mapped to UniProt Q00961. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutamate receptor ionotropic, NMDA 2C |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q00961 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, NMDA 2C |
| UniProt Accession | Q00961 |
| Component Type | Protein |
| Sequence Length | 1237 aa |
Glutamate receptor ionotropic, NMDA 2C
Review this target as Glutamate receptor ionotropic, NMDA 2C, mapped to UniProt Q00961. Sequence length is 1237 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL69034 | 8.22 | Ki | 6.0 | Preclinical |
| CHEMBL302321 | 8.15 | Ki | 7.0 | Preclinical |
| CHEMBL307113 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL19576 | 7.62 | IC50 | 24.0 | Preclinical |
| CHEMBL306450 | 7.48 | Ki | 33.0 | Preclinical |
| CHEMBL71302 | 7.43 | Ki | 37.0 | Preclinical |
| CHEMBL366809 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL319706 | 7.26 | IC50 | 55.0 | Preclinical |
| CHEMBL71834 | 7.25 | Ki | 56.0 | Preclinical |
| CHEMBL275528 | 7.22 | Ki | 60.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 32 | 30 | 5.5 |
| cell-based format | 22 | 66 | 5.5 |
| assay format | 8 | 10 | 5.2 |
| tissue-based format | 6 | 22 | 6.7 |
| cell membrane format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 0 | — |
| cell-based format | 7 | 3 | 5.0 |
| tissue-based format | 1 | 7 | 6.7 |