Assay Detail
Binding
CHEMBL748564
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro concentration eliciting half-maximal effect on [3H]-MK 801 radioligand binding to NMDA receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.98 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL773 | GLYCINE | 4.0 | 1 | 7.17 |
| CHEMBL285123 | (D)-SERINE | 3.0 | 1 | 6.80 |
| CHEMBL771 | CYCLOSERINE | 4.0 | 1 | 5.53 |
| CHEMBL286024 | — | — | 1 | 5.36 |
| CHEMBL283819 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL773 | GLYCINE | EC50 | = | 68.0 | nM | 7.17 |
| CHEMBL285123 | (D)-SERINE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL771 | CYCLOSERINE | EC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL286024 | — | EC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL283819 | — | EC50 | = | 9500.0 | nM | 5.02 |