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Assay Detail

CHEMBL4719106

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Functional
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth by microdilution alamar blue broth assay
ChEMBL ↗
96
Total Activities
32
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycobacterium tuberculosis (CHEMBL360) ↗
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

A facile stereoselective synthesis of dispiro-indeno pyrrolidine/pyrrolothiazole-thiochroman hybrids and evaluation of their antimycobacterial, anticancer and AchE inhibitory activities.
Bharkavi C,Vivek Kumar S,Ashraf Ali M,Osman H,Muthusubramanian S,Perumal S
Bioorg Med Chem (2016) 24 : 5873 -5883
PubMed 27687968 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
MIC 32 - -
IC90 32 - -
IC50 32 4.98 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL177 AMIKACIN 4.0 3 7.16
CHEMBL64 ISONIAZID 4.0 3 6.75
CHEMBL4780172 — — 3 5.97
CHEMBL4797884 — — 3 5.54
CHEMBL4799570 — — 3 5.37
CHEMBL4739877 — — 3 5.24
CHEMBL4794820 — — 3 5.16
CHEMBL4743869 — — 3 5.14
CHEMBL4744408 — — 3 5.07
CHEMBL4748587 — — 3 5.07
CHEMBL4791351 — — 3 4.96
CHEMBL771 CYCLOSERINE 4.0 3 4.90
CHEMBL4789991 — — 3 4.89
CHEMBL4752440 — — 3 4.89
CHEMBL4788300 — — 3 4.88
CHEMBL4800067 — — 3 4.82
CHEMBL4754171 — — 3 4.79
CHEMBL4761620 — — 3 4.79
CHEMBL4797575 — — 3 4.76
CHEMBL4755928 — — 3 4.74
CHEMBL4747183 — — 3 4.74
CHEMBL4762214 — — 3 4.66
CHEMBL4763528 — — 3 4.59
CHEMBL4791084 — — 3 4.59
CHEMBL4757955 — — 3 4.54
CHEMBL4760400 — — 3 4.54
CHEMBL4740786 — — 3 4.52
CHEMBL36 PYRIMETHAMINE 4.0 3 4.43
CHEMBL4756742 — — 3 4.35
CHEMBL4754607 — — 3 4.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL177 AMIKACIN IC50 = 70.0 nM 7.16
CHEMBL64 ISONIAZID IC50 = 180.0 nM 6.75
CHEMBL4780172 — IC50 = 1070.0 nM 5.97
CHEMBL4797884 — IC50 = 2870.0 nM 5.54
CHEMBL4799570 — IC50 = 4280.0 nM 5.37
CHEMBL4739877 — IC50 = 5810.0 nM 5.24
CHEMBL4794820 — IC50 = 6870.0 nM 5.16
CHEMBL4743869 — IC50 = 7200.0 nM 5.14
CHEMBL4744408 — IC50 = 8460.0 nM 5.07
CHEMBL4748587 — IC50 = 8570.0 nM 5.07
CHEMBL4791351 — IC50 = 11070.0 nM 4.96
CHEMBL771 CYCLOSERINE IC50 = 12470.0 nM 4.90
CHEMBL4752440 — IC50 = 12870.0 nM 4.89
CHEMBL4789991 — IC50 = 12870.0 nM 4.89
CHEMBL4788300 — IC50 = 13190.0 nM 4.88
CHEMBL4800067 — IC50 = 15170.0 nM 4.82
CHEMBL4754171 — IC50 = 16300.0 nM 4.79
CHEMBL4761620 — IC50 = 16380.0 nM 4.79
CHEMBL4797575 — IC50 = 17200.0 nM 4.76
CHEMBL4755928 — IC50 = 18280.0 nM 4.74
CHEMBL4747183 — IC50 = 18280.0 nM 4.74
CHEMBL4762214 — IC50 = 21910.0 nM 4.66
CHEMBL4763528 — IC50 = 25870.0 nM 4.59
CHEMBL4791084 — IC50 = 25870.0 nM 4.59
CHEMBL4757955 — IC50 = 28570.0 nM 4.54
CHEMBL4760400 — IC50 = 28570.0 nM 4.54
CHEMBL4740786 — IC50 = 29950.0 nM 4.52
CHEMBL36 PYRIMETHAMINE IC50 = 37350.0 nM 4.43
CHEMBL4756742 — IC50 = 44950.0 nM 4.35
CHEMBL4797045 — IC50 = 47200.0 nM 4.33
CHEMBL4754607 — IC50 = 47200.0 nM 4.33
CHEMBL4739877 — MIC = 25000.0 nM -
CHEMBL4756742 — MIC = 100000.0 nM -
CHEMBL4743869 — IC90 = 15500.0 nM -
CHEMBL4791351 — IC90 = 21980.0 nM -
CHEMBL4744408 — IC90 = 12420.0 nM -
CHEMBL4740786 — IC90 = 41870.0 nM -
CHEMBL4800067 — IC90 = 27860.0 nM -
CHEMBL4797045 — IC90 = 66500.0 nM -
CHEMBL4791084 — IC90 = 44600.0 nM -
CHEMBL4747183 — IC90 = 36500.0 nM -
CHEMBL4799570 — IC90 = 9860.0 nM -
CHEMBL4739877 — IC90 = 16130.0 nM -
CHEMBL4754607 — IC90 = 66500.0 nM -
CHEMBL4755928 — IC90 = 36500.0 nM -
CHEMBL4780172 — IC90 = 1980.0 nM -
CHEMBL4794820 — IC90 = 14600.0 nM -
CHEMBL4763528 — IC90 = 44600.0 nM -
CHEMBL44884 ETHAMBUTOL IC50 < 1560.0 nM -
CHEMBL4788300 — IC90 = 25900.0 nM -