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Assay Detail

CHEMBL3367829

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Functional
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by microdilution AlamarBlue broth assay
ChEMBL ↗
129
Total Activities
43
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycobacterium tuberculosis (CHEMBL360) ↗
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

Sequential synthesis of amino-1,4-naphthoquinone-appended triazoles and triazole-chromene hybrids and their antimycobacterial evaluation.
Devi Bala B, Muthusaravanan S, Choon TS, Ashraf Ali M, Perumal S.
Eur J Med Chem (2014) 85 : 737 -746
PubMed 25129868 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 5.00 7.16
IC90 43 - -
MIC 43 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL177 AMIKACIN 4.0 3 7.16
CHEMBL64 ISONIAZID 4.0 3 6.75
CHEMBL3354606 — — 3 5.73
CHEMBL3331410 — — 3 5.59
CHEMBL3331392 — — 3 5.55
CHEMBL3331427 — — 3 5.50
CHEMBL3331398 — — 3 5.48
CHEMBL3331414 — — 3 5.27
CHEMBL3331403 — — 3 5.23
CHEMBL3331406 — — 3 5.20
CHEMBL3331420 — — 3 5.14
CHEMBL3331397 — — 3 5.07
CHEMBL3331422 — — 3 5.07
CHEMBL3331395 — — 3 5.00
CHEMBL3331394 — — 3 4.97
CHEMBL3329241 — — 3 4.95
CHEMBL3331396 — — 3 4.92
CHEMBL771 CYCLOSERINE 4.0 3 4.90
CHEMBL3331417 — — 3 4.88
CHEMBL3331415 — — 3 4.85
CHEMBL3331413 — — 3 4.82
CHEMBL3331405 — — 3 4.82
CHEMBL3331393 — — 3 4.79
CHEMBL3331408 — — 3 4.77
CHEMBL3331399 — — 3 4.76
CHEMBL3331401 — — 3 4.74
CHEMBL3331428 — — 3 4.73
CHEMBL3331400 — — 3 4.73
CHEMBL3331423 — — 3 4.73
CHEMBL3331416 — — 3 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL177 AMIKACIN IC50 = 70.0 nM 7.16
CHEMBL64 ISONIAZID IC50 = 180.0 nM 6.75
CHEMBL3354606 — IC50 = 1870.0 nM 5.73
CHEMBL3331410 — IC50 = 2580.0 nM 5.59
CHEMBL3331392 — IC50 = 2810.0 nM 5.55
CHEMBL3331427 — IC50 = 3180.0 nM 5.50
CHEMBL3331398 — IC50 = 3280.0 nM 5.48
CHEMBL3331414 — IC50 = 5380.0 nM 5.27
CHEMBL3331403 — IC50 = 5870.0 nM 5.23
CHEMBL3331406 — IC50 = 6380.0 nM 5.20
CHEMBL3331420 — IC50 = 7200.0 nM 5.14
CHEMBL3331422 — IC50 = 8570.0 nM 5.07
CHEMBL3331397 — IC50 = 8460.0 nM 5.07
CHEMBL3331395 — IC50 = 9950.0 nM 5.00
CHEMBL3331394 — IC50 = 10640.0 nM 4.97
CHEMBL3329241 — IC50 = 11190.0 nM 4.95
CHEMBL3331396 — IC50 = 11910.0 nM 4.92
CHEMBL771 CYCLOSERINE IC50 = 12470.0 nM 4.90
CHEMBL3331417 — IC50 = 13280.0 nM 4.88
CHEMBL3331415 — IC50 = 14000.0 nM 4.85
CHEMBL3331413 — IC50 = 15300.0 nM 4.82
CHEMBL3331405 — IC50 = 15300.0 nM 4.82
CHEMBL3331393 — IC50 = 16300.0 nM 4.79
CHEMBL3331408 — IC50 = 17000.0 nM 4.77
CHEMBL3331399 — IC50 = 17200.0 nM 4.76
CHEMBL3331401 — IC50 = 18280.0 nM 4.74
CHEMBL3331400 — IC50 = 18570.0 nM 4.73
CHEMBL3331423 — IC50 = 18570.0 nM 4.73
CHEMBL3331428 — IC50 = 18570.0 nM 4.73
CHEMBL3331416 — IC50 = 19110.0 nM 4.72
CHEMBL3331419 — IC50 = 19200.0 nM 4.72
CHEMBL3331402 — IC50 = 21580.0 nM 4.67
CHEMBL3331425 — IC50 = 21580.0 nM 4.67
CHEMBL3331426 — IC50 = 21870.0 nM 4.66
CHEMBL3331421 — IC50 = 23870.0 nM 4.62
CHEMBL3331412 — IC50 = 24950.0 nM 4.60
CHEMBL3331404 — IC50 = 24950.0 nM 4.60
CHEMBL3331407 — IC50 = 25520.0 nM 4.59
CHEMBL3331424 — IC50 = 27200.0 nM 4.57
CHEMBL3331409 — IC50 = 28710.0 nM 4.54
CHEMBL3331418 — IC50 = 28570.0 nM 4.54
CHEMBL36 PYRIMETHAMINE IC50 = 37350.0 nM 4.43
CHEMBL3331402 — MIC = 50000.0 nM -
CHEMBL3331403 — MIC = 25000.0 nM -
CHEMBL3331404 — MIC = 50000.0 nM -
CHEMBL3331405 — MIC = 50000.0 nM -
CHEMBL3331406 — MIC = 25000.0 nM -
CHEMBL3331409 — MIC = 100000.0 nM -
CHEMBL3354606 — MIC = 10000.0 nM -
CHEMBL3331410 — MIC = 25000.0 nM -