Compound Detail
CHEMBL61315
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Basic Information
| ChEMBL ID | CHEMBL61315 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PFABOWHTRBDUCE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
351.5
MW (Da)
2.40
ALogP
3
HBA
2
HBD
66.4
PSA (Ų)
0.76
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 6.44 | 6.44 | 360.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 360.0 | nM | 6.44 | In vitro inhibition of [3H]glycine at NMDA receptor | 7990104 |
| Glutamate NMDA receptor | IC50 | = | 360.0 | nM | 6.44 | Concentration required to inhibit 50% of the specific binding of [3H]glycine to ... | 1534583 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7990104 | 10.1021/jm00050a001 | Glutamate NMDA receptor | 2 |
| 1534583 | 10.1021/jm00089a003 | Glutamate NMDA receptor | 1 |
| 1534583 | 10.1021/jm00089a003 | Glutamate receptors; NMDA/AMPA | 1 |
Data from ChEMBL 36 via Core Engine