Assay Detail
Binding
CHEMBL5041141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat GluN1/GluN2B NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2b (CHEMBL2096666) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Derivatives of (<i>R</i>)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.42 | 6.62 |
| IC50 | 2 | 5.00 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL773 | GLYCINE | 4.0 | 1 | 6.62 |
| CHEMBL285123 | (D)-SERINE | 3.0 | 1 | 6.21 |
| CHEMBL5081008 | — | — | 1 | 5.00 |
| CHEMBL5090386 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL773 | GLYCINE | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL285123 | (D)-SERINE | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5081008 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5090386 | — | IC50 | = | 10000.0 | nM | 5.00 |