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Compound Detail

CHEMBL5090386

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N[C@H](CNC(=O)c1ccc(-c2ccc(Cl)cc2[N+](=O)[O-])o1)C(=O)O

Basic Information

ChEMBL ID CHEMBL5090386
Phase Preclinical
Structure Type MOL
InChI Key GQMUKVINJQUGGQ-SECBINFHSA-N
3
Targets
3
Activities
3
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

353.7
MW (Da)
1.65
ALogP
6
HBA
3
HBD
148.7
PSA (Ų)
0.53
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H12ClN3O6
MW 353.72
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.14

Activity Summary

EC50 1 meas. best 7.13
IC50 1 meas. best 5.0
Ki 1 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Glutamate NMDA receptor; Grin1/Grin2c
CHEMBL2096911
EC50 7.13 7.13 74.0 1
Unchecked
CHEMBL612545
Ki 7.0 7.0 100.0 1
Glutamate NMDA receptor; Grin1/Grin2b
CHEMBL2096666
IC50 5.0 5.0 10000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
34918931 10.1021/acs.jmedchem.1c01810 Unchecked 5
34918931 10.1021/acs.jmedchem.1c01810 Glutamate NMDA receptor; Grin1/Grin2b 2
34918931 10.1021/acs.jmedchem.1c01810 Glutamate NMDA receptor; Grin1/Grin2c 2
34918931 10.1021/acs.jmedchem.1c01810 Ionotropic glutamate receptor NMDA 1/2D 1

Data from ChEMBL 36 via Core Engine