Assay Detail
Binding
CHEMBL5041142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat GluN1/GluN2C NMDA receptor expressed in Xenopus oocytes measured after 4 days in presence of L-glutamte by two-electrode voltage-clamp recording assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor; Grin1/Grin2c (CHEMBL2096911) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Derivatives of (<i>R</i>)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.23 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5081078 | — | — | 1 | 7.44 |
| CHEMBL5087374 | — | — | 1 | 7.40 |
| CHEMBL5081008 | — | — | 1 | 7.20 |
| CHEMBL5090386 | — | — | 1 | 7.13 |
| CHEMBL5091289 | — | — | 1 | 6.96 |
| CHEMBL5081203 | — | — | 1 | 6.92 |
| CHEMBL5085583 | — | — | 1 | 6.85 |
| CHEMBL285123 | (D)-SERINE | 3.0 | 1 | 6.72 |
| CHEMBL773 | GLYCINE | 4.0 | 1 | 6.68 |
| CHEMBL5092220 | — | — | 1 | 6.12 |
| CHEMBL5075942 | — | — | 1 | 5.89 |
| CHEMBL5076681 | — | — | 1 | 5.89 |
| CHEMBL5087170 | — | — | 1 | 5.80 |
| CHEMBL5093773 | — | — | 1 | 5.77 |
| CHEMBL5087550 | — | — | 1 | 5.75 |
| CHEMBL5072895 | — | — | 1 | 5.54 |
| CHEMBL5091158 | — | — | 1 | 5.41 |
| CHEMBL5079391 | — | — | 1 | 5.40 |
| CHEMBL5083882 | — | — | 1 | 5.38 |
| CHEMBL5081696 | — | — | 1 | 5.32 |
| CHEMBL5079035 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5081078 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL5087374 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5081008 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL5090386 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5091289 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5081203 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5085583 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL285123 | (D)-SERINE | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL773 | GLYCINE | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5092220 | — | EC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5075942 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5076681 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5087170 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5093773 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5087550 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5072895 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5091158 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5079391 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL5083882 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5081696 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5079035 | — | EC50 | = | 5800.0 | nM | 5.24 |