Assay Detail
Binding
CHEMBL752486
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Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 1 (CHEMBL330) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Beta-proline analogues as agonists at the strychnine-sensitive glycine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.74 | 5.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL773 | GLYCINE | 4.0 | 1 | 5.21 |
| CHEMBL311110 | — | — | 1 | 5.10 |
| CHEMBL54922 | PROLINE | 2.0 | 2 | 4.76 |
| CHEMBL310435 | — | — | 1 | 4.62 |
| CHEMBL279998 | ISONIPECOTIC ACID | — | 1 | 4.03 |
| CHEMBL33592 | — | — | 1 | - |
| CHEMBL310623 | — | — | 1 | - |
| CHEMBL279597 | ALANINE | 3.0 | 1 | - |
| CHEMBL432561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL773 | GLYCINE | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL311110 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL54922 | PROLINE | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL310435 | — | IC50 | = | 23700.0 | nM | 4.62 |
| CHEMBL279998 | ISONIPECOTIC ACID | IC50 | = | 94100.0 | nM | 4.03 |
| CHEMBL33592 | — | IC50 | = | 399000.0 | nM | - |
| CHEMBL310623 | — | IC50 | = | 242000.0 | nM | - |
| CHEMBL279597 | ALANINE | IC50 | = | 198000.0 | nM | - |
| CHEMBL54922 | PROLINE | IC50 | = | 414000.0 | nM | - |
| CHEMBL432561 | — | IC50 | = | 694000.0 | nM | - |