Assay Detail
Binding
CHEMBL751457
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Compound was evaluated for in vitro inhibition of [3H]TCP at NMDA receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.28 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL773 | GLYCINE | 4.0 | 1 | 6.70 |
| CHEMBL285123 | (D)-SERINE | 3.0 | 1 | 6.70 |
| CHEMBL336423 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL773 | GLYCINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL285123 | (D)-SERINE | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL336423 | — | EC50 | = | 3600.0 | nM | 5.44 |