Assay Detail
Binding
CHEMBL749369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for binding affinity against NMDA receptor, from rat synaptic membrane, using [3H]glycine as the radioligand.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Potent quinoxaline-spaced phosphono alpha-amino acids of the AP-6 type as competitive NMDA antagonists: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.09 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL773 | GLYCINE | 4.0 | 1 | 7.07 |
| CHEMBL42990 | — | — | 1 | 6.21 |
| CHEMBL115671 | — | — | 1 | 5.75 |
| CHEMBL324706 | — | — | 1 | 5.33 |
| CHEMBL116797 | — | — | 1 | - |
| CHEMBL22304 | — | — | 1 | - |
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL773 | GLYCINE | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL42990 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL115671 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL324706 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL116797 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL22304 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL39664 | SELFOTEL | IC50 | > | 100000.0 | nM | - |