Glutamate receptor ionotropic, NMDA 2B · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q13224. Use UniProt Q13224 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q13224 as the stable identity anchor, then attach disease evidence before program review.
Glutamate receptor ionotropic, NMDA 2B
Review this target as Glutamate receptor ionotropic, NMDA 2B, mapped to UniProt Q13224. Sequence length is 1484 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glutamate receptor ionotropic, NMDA 2B as ChEMBL target CHEMBL1904, mapped to UniProt Q13224. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glutamate receptor ionotropic, NMDA 2B |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13224 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glutamate receptor ionotropic, NMDA 2B |
| UniProt Accession | Q13224 |
| Component Type | Protein |
| Sequence Length | 1484 aa |
Glutamate receptor ionotropic, NMDA 2B
Review this target as Glutamate receptor ionotropic, NMDA 2B, mapped to UniProt Q13224. Sequence length is 1484 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL161180 | 9.22 | Ki | 0.6 | Preclinical |
| CHEMBL158737 | 9.15 | Ki | 0.7 | Preclinical |
| CHEMBL158737 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL159744 | 8.92 | Ki | 1.2 | Preclinical |
| CHEMBL219060 | 8.8 | EC50 | 1.6 | Preclinical |
| CHEMBL3735947 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL429656 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL4302264 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL5757337 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4637295 | 8.68 | Ki | 2.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 105 | 1,429 | 6.9 |
| single protein format | 27 | 403 | 6.0 |
| assay format | 24 | 114 | 6.5 |
| cell membrane format | 4 | 44 | 7.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 32 | 6.5 |
| assay format | 3 | 12 | 6.6 |