Assay Detail
Binding
CHEMBL4315422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from GluN1A/GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes after 120 mins by solid scintillation counting method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.24 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.00 |
| CHEMBL3357784 | — | — | 1 | 8.00 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 7.89 |
| CHEMBL4294561 | — | — | 1 | 7.80 |
| CHEMBL296601 | — | — | 1 | 7.80 |
| CHEMBL4284348 | — | — | 1 | 7.68 |
| CHEMBL4286654 | — | — | 1 | 7.55 |
| CHEMBL4473586 | — | — | 1 | 7.31 |
| CHEMBL4448528 | — | — | 1 | 7.19 |
| CHEMBL4561134 | — | — | 1 | 7.11 |
| CHEMBL4536973 | — | — | 1 | 6.85 |
| CHEMBL305195 | — | — | 1 | 6.77 |
| CHEMBL4550150 | — | — | 1 | 6.57 |
| CHEMBL4453563 | — | — | 1 | 6.42 |
| CHEMBL4436519 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3357784 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL28564 | ELIPRODIL | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4294561 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL296601 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4284348 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL4286654 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL4473586 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL4448528 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL4561134 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL4536973 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL305195 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL4550150 | — | Ki | = | 270.0 | nM | 6.57 |
| CHEMBL4453563 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL4436519 | — | Ki | = | 2000.0 | nM | 5.70 |