Assay Detail
Binding
CHEMBL5513484
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Inhibition of rat TSPO
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting autophagy drug discovery: Targets, indications and development trends.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.64 | 9.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 9.60 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 9.30 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 9.14 |
| CHEMBL470881 | OXOGLAUCINE | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL305187 | IFENPRODIL | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL470881 | OXOGLAUCINE | IC50 | = | 300.0 | nM | 6.52 |