Assay Detail
Binding
CHEMBL4480642
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ifenprodil from GluN2B (unknown origin) expressed in rat L(tk) cells measured after 120 mins by scintillation counting analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.38 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.00 |
| CHEMBL4287203 | — | — | 1 | 7.80 |
| CHEMBL4574247 | — | — | 1 | 7.58 |
| CHEMBL4590193 | — | — | 1 | 7.32 |
| CHEMBL4570472 | — | — | 1 | 6.89 |
| CHEMBL4513837 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4287203 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4574247 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4590193 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL4570472 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL4513837 | — | Ki | = | 204.0 | nM | 6.69 |