Assay Detail
Binding
CHEMBL804438
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Inhibition of [3H]-emopamil binding to Sterol delta 8-delta 7 isomerase in guinea pig liver membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CHEMBL5525) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Synthesis of chiral 1-[omega-(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at sigma1, sigma2, and sterol delta8-delta7 isomerase sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.96 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.57 |
| CHEMBL542392 | — | — | 1 | 8.47 |
| CHEMBL555790 | — | — | 1 | 8.43 |
| CHEMBL543821 | — | — | 1 | 8.43 |
| CHEMBL545691 | — | — | 1 | 8.11 |
| CHEMBL540289 | — | — | 1 | 8.02 |
| CHEMBL543581 | — | — | 1 | 7.92 |
| CHEMBL539776 | — | — | 1 | 7.84 |
| CHEMBL543105 | — | — | 1 | 7.73 |
| CHEMBL542873 | — | — | 1 | 7.56 |
| CHEMBL555090 | — | — | 1 | 7.52 |
| CHEMBL545451 | — | — | 1 | 7.46 |
| CHEMBL544524 | — | — | 1 | 7.43 |
| CHEMBL544992 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | Ki | = | 2.71 | nM | 8.57 |
| CHEMBL542392 | — | Ki | = | 3.38 | nM | 8.47 |
| CHEMBL555790 | — | Ki | = | 3.73 | nM | 8.43 |
| CHEMBL543821 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL545691 | — | Ki | = | 7.79 | nM | 8.11 |
| CHEMBL540289 | — | Ki | = | 9.65 | nM | 8.02 |
| CHEMBL543581 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL539776 | — | Ki | = | 14.5 | nM | 7.84 |
| CHEMBL543105 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL542873 | — | Ki | = | 27.5 | nM | 7.56 |
| CHEMBL555090 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL545451 | — | Ki | = | 35.1 | nM | 7.46 |
| CHEMBL544524 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL544992 | — | Ki | > | - | nM | - |