Assay Detail
Binding
CHEMBL5365001
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L-M(TK-) cell membrane coexpressing GluN1a assessed as inhibition constant measured after 120 mins by competitive binding assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | L-M(TK-) |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.52 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5410173 | — | — | 1 | 8.24 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.24 |
| CHEMBL5421604 | — | — | 1 | 8.18 |
| CHEMBL114644 | — | — | 1 | 7.96 |
| CHEMBL5441115 | — | — | 1 | 7.92 |
| CHEMBL5435194 | — | — | 1 | 7.89 |
| CHEMBL5432456 | — | — | 1 | 7.89 |
| CHEMBL5398972 | — | — | 1 | 7.75 |
| CHEMBL5423529 | — | — | 1 | 7.70 |
| CHEMBL5406518 | — | — | 1 | 7.70 |
| CHEMBL5409908 | — | — | 1 | 7.60 |
| CHEMBL5396018 | — | — | 1 | 7.54 |
| CHEMBL5410339 | — | — | 1 | 7.50 |
| CHEMBL5429038 | — | — | 1 | 7.46 |
| CHEMBL5432037 | — | — | 1 | 7.42 |
| CHEMBL5416753 | — | — | 1 | 7.42 |
| CHEMBL5425955 | — | — | 1 | 7.42 |
| CHEMBL5408501 | — | — | 1 | 7.38 |
| CHEMBL5435626 | — | — | 1 | 7.28 |
| CHEMBL5431988 | — | — | 1 | 7.25 |
| CHEMBL5417143 | — | — | 1 | 7.03 |
| CHEMBL5440346 | — | — | 1 | 6.92 |
| CHEMBL5403196 | — | — | 1 | 6.87 |
| CHEMBL5394862 | — | — | 1 | 6.74 |
| CHEMBL5435354 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5410173 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL5421604 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL114644 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL5441115 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL5435194 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5432456 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL5398972 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL5423529 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5406518 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL5409908 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL5396018 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL5410339 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL5429038 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL5432037 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL5416753 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL5425955 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL5408501 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL5435626 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL5431988 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL5417143 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL5440346 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL5403196 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL5394862 | — | Ki | = | 182.0 | nM | 6.74 |
| CHEMBL5435354 | — | Ki | = | 265.0 | nM | 6.58 |