Compound Detail
CHEMBL5417143
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Basic Information
| ChEMBL ID | CHEMBL5417143 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLLHDEONAMMACT-QFIPXVFZSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
349.5
MW (Da)
3.94
ALogP
3
HBA
2
HBD
52.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.07
IC50 1 meas. best 7.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | IC50 | 7.14 | 7.14 | 72.0 | 1 |
| Sigma non-opioid intracellular receptor 1 CHEMBL4153 | Ki | 7.07 | 7.07 | 86.0 | 1 |
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | Ki | 7.03 | 7.03 | 93.0 | 1 |
| Sigma intracellular receptor 2 CHEMBL4105864 | Ki | 6.91 | 6.91 | 124.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B | IC50 | = | 72.0 | nM | 7.14 | Antagonist activity at GluN2B receptor (unknown origin) expressed in Xenopus ooc... | 37580890 |
| Sigma non-opioid intracellular receptor 1 | Ki | = | 86.0 | nM | 7.07 | Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain me... | 37580890 |
| Glutamate receptor ionotropic, NMDA 2B | Ki | = | 93.0 | nM | 7.03 | Displacement of [3H]ifenprodil from human GluN2B expressed in mouse L-M(TK-) cel... | 37580890 |
| Sigma intracellular receptor 2 | Ki | = | 124.0 | nM | 6.91 | Displacement of [3H]di-o-tolylguanidine from sigma2 receptor in rat liver membra... | 37580890 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37580890 | 10.1021/acs.jmedchem.3c01161 | Glutamate receptor ionotropic, NMDA 2B | 2 |
| 37580890 | 10.1021/acs.jmedchem.3c01161 | ADMET | 2 |
| 37580890 | 10.1021/acs.jmedchem.3c01161 | Sigma non-opioid intracellular receptor 1 | 1 |
| 37580890 | 10.1021/acs.jmedchem.3c01161 | Sigma intracellular receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine