Assay Detail
Binding
CHEMBL5365007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at GluN2B receptor (unknown origin) expressed in Xenopus oocytes coexpressing GluN1a at -70 mV holding potential in presence of (S)-glutamate/glycine by TEVC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.98 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5435354 | — | — | 1 | 7.21 |
| CHEMBL5417143 | — | — | 1 | 7.14 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5435354 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5417143 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL305187 | IFENPRODIL | IC50 | = | 264.0 | nM | 6.58 |