Assay Detail
Functional
CHEMBL2188405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Neuroprotective activity in human SH-SY5Y cells assessed as protection against NMDA-induced cell death after 6 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.31 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2178785 | — | — | 1 | 9.68 |
| CHEMBL2178784 | MEMAGAL | — | 1 | 9.55 |
| CHEMBL2178781 | — | — | 1 | 9.43 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 9.14 |
| CHEMBL344151 | DIZOCILPINE MALEATE | -1.0 | 1 | 8.10 |
| CHEMBL807 | MEMANTINE | 4.0 | 1 | 6.14 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.13 |
| CHEMBL2178791 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2178785 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL2178784 | MEMAGAL | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL2178781 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL305187 | IFENPRODIL | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL344151 | DIZOCILPINE MALEATE | IC50 | = | 7.91 | nM | 8.10 |
| CHEMBL807 | MEMANTINE | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 747.0 | nM | 6.13 |
| CHEMBL2178791 | — | IC50 | > | 10000.0 | nM | - |