Assay Detail
Binding
CHEMBL4192534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from recombinant human GluN1A/GluN2B receptor expressed in mouse L(tk-) cell membranes after 120 mins by microbeta scintillation counting method
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 6.86 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217195 | — | — | 1 | 8.66 |
| CHEMBL4208912 | — | — | 1 | 8.22 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.00 |
| CHEMBL28564 | ELIPRODIL | 2.0 | 1 | 7.89 |
| CHEMBL4207886 | — | — | 1 | 7.80 |
| CHEMBL4216511 | — | — | 1 | 7.17 |
| CHEMBL4216762 | — | — | 1 | 7.12 |
| CHEMBL4204069 | — | — | 1 | 6.96 |
| CHEMBL4208375 | — | — | 1 | 6.96 |
| CHEMBL4212243 | — | — | 1 | 6.89 |
| CHEMBL4213309 | — | — | 1 | 6.68 |
| CHEMBL4215178 | — | — | 1 | 6.64 |
| CHEMBL4203530 | — | — | 1 | 6.62 |
| CHEMBL4217716 | — | — | 1 | 6.60 |
| CHEMBL4215077 | — | — | 1 | 6.52 |
| CHEMBL4208409 | — | — | 1 | 6.11 |
| CHEMBL4204035 | — | — | 1 | 6.05 |
| CHEMBL4203405 | — | — | 1 | 6.00 |
| CHEMBL4215740 | — | — | 1 | 5.80 |
| CHEMBL4204319 | — | — | 1 | 5.80 |
| CHEMBL4212766 | — | — | 1 | 5.55 |
| CHEMBL4212788 | — | — | 1 | - |
| CHEMBL4205477 | — | — | 1 | - |
| CHEMBL4211795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217195 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4208912 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL28564 | ELIPRODIL | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL4207886 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4216511 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL4216762 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL4204069 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4208375 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4212243 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL4213309 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL4215178 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL4203530 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL4217716 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4215077 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL4208409 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL4204035 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL4203405 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL4215740 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4204319 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL4212766 | — | Ki | = | 2807.0 | nM | 5.55 |
| CHEMBL4212788 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4205477 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4211795 | — | Ki | > | 1000.0 | nM | - |