Assay Detail
Binding
CHEMBL4615566
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ifenprodil from GluN2B (unknown origin) expressed in mouse L(tk-) cell membranes co-expressing GluN1a incubated for 120 mins by scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL1904) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.80 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.00 |
| CHEMBL4643805 | — | — | 1 | 7.23 |
| CHEMBL4644807 | — | — | 1 | 7.10 |
| CHEMBL4640137 | — | — | 1 | 6.97 |
| CHEMBL4643145 | — | — | 1 | 6.94 |
| CHEMBL4636728 | — | — | 1 | 6.53 |
| CHEMBL4633788 | — | — | 1 | 5.82 |
| CHEMBL4639180 | — | — | 1 | 5.80 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305187 | IFENPRODIL | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4643805 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL4644807 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL4640137 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL4643145 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL4636728 | — | Ki | = | 294.0 | nM | 6.53 |
| CHEMBL4633788 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL4639180 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL54 | HALOPERIDOL | Ki | - | — | - | |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | - | — | - |