Assay Detail
Binding
CHEMBL860172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](+/-)-emopamil from delta8-delta7 sterol isomerase (SI) site in guinea pig liver membranes
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (CHEMBL5525) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.07 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL540563 | — | — | 1 | 8.74 |
| CHEMBL544343 | — | — | 1 | 8.72 |
| CHEMBL545508 | — | — | 1 | 8.55 |
| CHEMBL554663 | — | — | 1 | 8.47 |
| CHEMBL537842 | — | — | 1 | 8.45 |
| CHEMBL540818 | — | — | 1 | 8.39 |
| CHEMBL305187 | IFENPRODIL | 2.0 | 1 | 8.33 |
| CHEMBL534695 | — | — | 1 | 8.27 |
| CHEMBL538566 | — | — | 1 | 8.27 |
| CHEMBL540573 | — | — | 1 | 8.26 |
| CHEMBL535363 | — | — | 1 | 8.19 |
| CHEMBL559377 | — | — | 1 | 8.14 |
| CHEMBL545278 | — | — | 1 | 8.10 |
| CHEMBL537177 | — | — | 1 | 8.06 |
| CHEMBL539545 | — | — | 1 | 8.05 |
| CHEMBL536483 | — | — | 1 | 8.04 |
| CHEMBL542701 | — | — | 1 | 7.96 |
| CHEMBL554450 | — | — | 1 | 7.93 |
| CHEMBL539333 | — | — | 1 | 7.84 |
| CHEMBL190883 | — | — | 1 | 7.84 |
| CHEMBL540361 | — | — | 1 | 7.83 |
| CHEMBL537399 | — | — | 1 | 7.79 |
| CHEMBL558980 | — | — | 1 | 7.75 |
| CHEMBL535366 | — | — | 1 | 7.71 |
| CHEMBL559178 | — | — | 1 | 7.71 |
| CHEMBL552542 | — | — | 1 | 7.71 |
| CHEMBL553091 | — | — | 1 | 7.42 |
| CHEMBL538772 | — | — | 1 | 7.33 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL540563 | — | Ki | = | 1.82 | nM | 8.74 |
| CHEMBL544343 | — | Ki | = | 1.89 | nM | 8.72 |
| CHEMBL545508 | — | Ki | = | 2.81 | nM | 8.55 |
| CHEMBL554663 | — | Ki | = | 3.41 | nM | 8.47 |
| CHEMBL537842 | — | Ki | = | 3.57 | nM | 8.45 |
| CHEMBL540818 | — | Ki | = | 4.11 | nM | 8.39 |
| CHEMBL305187 | IFENPRODIL | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL534695 | — | Ki | = | 5.34 | nM | 8.27 |
| CHEMBL538566 | — | Ki | = | 5.39 | nM | 8.27 |
| CHEMBL540573 | — | Ki | = | 5.55 | nM | 8.26 |
| CHEMBL535363 | — | Ki | = | 6.44 | nM | 8.19 |
| CHEMBL559377 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL545278 | — | Ki | = | 8.04 | nM | 8.10 |
| CHEMBL537177 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL539545 | — | Ki | = | 8.97 | nM | 8.05 |
| CHEMBL536483 | — | Ki | = | 9.04 | nM | 8.04 |
| CHEMBL542701 | — | Ki | = | 11.1 | nM | 7.96 |
| CHEMBL554450 | — | Ki | = | 11.7 | nM | 7.93 |
| CHEMBL539333 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL190883 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL540361 | — | Ki | = | 14.9 | nM | 7.83 |
| CHEMBL537399 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL558980 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL535366 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL559178 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL552542 | — | Ki | = | 19.3 | nM | 7.71 |
| CHEMBL553091 | — | Ki | = | 37.6 | nM | 7.42 |
| CHEMBL538772 | — | Ki | = | 46.5 | nM | 7.33 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | > | 10000.0 | nM | - |