Assay Detail
Functional
CHEMBL1000153
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Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the delivery of glycan-based paclitaxel prodrugs to cancer cells via glucose transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.64 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.21 |
| CHEMBL508383 | — | — | 1 | 7.00 |
| CHEMBL499652 | — | — | 1 | 6.34 |
| CHEMBL445422 | — | — | 1 | 6.33 |
| CHEMBL509765 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL508383 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL499652 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL445422 | — | IC50 | = | 469.0 | nM | 6.33 |
| CHEMBL509765 | — | IC50 | = | 480.0 | nM | 6.32 |