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Assay Detail

CHEMBL1000356

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Functional
Antiviral activity against HIV2 ROD in human MT4 cells assessed as inhibition of viral replication by MTT assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 2
Cell Type MT4
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 2 (CHEMBL380)
Type ORGANISM
Organism Human immunodeficiency virus 2

Publication

Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.
Xiong YZ, Chen FE, Balzarini J, De Clercq E, Pannecouque C.
Eur J Med Chem (2008) 43 : 1230 -1236
PubMed 17869386 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 4.94 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1460 DIDANOSINE 4.0 1 5.57
CHEMBL461994 1 5.21
CHEMBL453086 1 5.18
CHEMBL453345 1 5.01
CHEMBL462342 1 4.98
CHEMBL462167 1 4.80
CHEMBL517591 1 4.71
CHEMBL517404 1 4.70
CHEMBL488701 1 4.34
CHEMBL461993 1 -
CHEMBL461992 1 -
CHEMBL518361 1 -
CHEMBL462341 1 -
CHEMBL460078 1 -
CHEMBL462182 1 -
CHEMBL462181 1 -
CHEMBL453346 1 -
CHEMBL453355 1 -
CHEMBL454666 1 -
CHEMBL455140 1 -
CHEMBL488702 1 -
CHEMBL488015 1 -
CHEMBL488014 1 -
CHEMBL488862 1 -
CHEMBL454907 1 -
CHEMBL454665 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1460 DIDANOSINE IC50 = 2710.0 nM 5.57
CHEMBL461994 IC50 = 6170.0 nM 5.21
CHEMBL453086 IC50 = 6590.0 nM 5.18
CHEMBL453345 IC50 = 9710.0 nM 5.01
CHEMBL462342 IC50 = 10470.0 nM 4.98
CHEMBL462167 IC50 = 15950.0 nM 4.80
CHEMBL517591 IC50 = 19700.0 nM 4.71
CHEMBL517404 IC50 = 20200.0 nM 4.70
CHEMBL488701 IC50 = 45580.0 nM 4.34
CHEMBL461993 IC50 >= 5300.0 nM -
CHEMBL461992 IC50 > 170600.0 nM -
CHEMBL518361 IC50 > 91850.0 nM -
CHEMBL462341 IC50 >= 43620.0 nM -
CHEMBL460078 IC50 >= 58300.0 nM -
CHEMBL462182 IC50 >= 28190.0 nM -
CHEMBL462181 IC50 > 193900.0 nM -
CHEMBL453346 IC50 > 41540.0 nM -
CHEMBL453355 IC50 > 74470.0 nM -
CHEMBL454666 IC50 > 39060.0 nM -
CHEMBL455140 IC50 >= 11470.0 nM -
CHEMBL488702 IC50 > 250760.0 nM -
CHEMBL488015 IC50 > 207700.0 nM -
CHEMBL488014 IC50 >= 12600.0 nM -
CHEMBL488862 IC50 > 196890.0 nM -
CHEMBL454907 IC50 > 73150.0 nM -
CHEMBL454665 IC50 > 30330.0 nM -