Assay Detail
Functional
CHEMBL1000357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV 3B in human MT4 cells assessed as inhibition of viral replication by MTT assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 11: structural modulations of diaryltriazines with potent anti-HIV activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.84 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517404 | — | — | 1 | 8.03 |
| CHEMBL462182 | — | — | 1 | 8.03 |
| CHEMBL461992 | — | — | 1 | 7.93 |
| CHEMBL518361 | — | — | 1 | 7.74 |
| CHEMBL462342 | — | — | 1 | 7.71 |
| CHEMBL461993 | — | — | 1 | 7.54 |
| CHEMBL461994 | — | — | 1 | 7.22 |
| CHEMBL488014 | — | — | 1 | 7.21 |
| CHEMBL517591 | — | — | 1 | 7.09 |
| CHEMBL455140 | — | — | 1 | 7.05 |
| CHEMBL488862 | — | — | 1 | 7.03 |
| CHEMBL454666 | — | — | 1 | 6.97 |
| CHEMBL462167 | — | — | 1 | 6.94 |
| CHEMBL453355 | — | — | 1 | 6.81 |
| CHEMBL462341 | — | — | 1 | 6.73 |
| CHEMBL454665 | — | — | 1 | 6.73 |
| CHEMBL460078 | — | — | 1 | 6.69 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.60 |
| CHEMBL453086 | — | — | 1 | 6.59 |
| CHEMBL488702 | — | — | 1 | 6.58 |
| CHEMBL462181 | — | — | 1 | 6.55 |
| CHEMBL453345 | — | — | 1 | 6.16 |
| CHEMBL488015 | — | — | 1 | 6.13 |
| CHEMBL453346 | — | — | 1 | 5.97 |
| CHEMBL488701 | — | — | 1 | 5.79 |
| CHEMBL454907 | — | — | 1 | 5.57 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517404 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL462182 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL461992 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL518361 | — | IC50 | = | 18.4 | nM | 7.74 |
| CHEMBL462342 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL461993 | — | IC50 | = | 28.7 | nM | 7.54 |
| CHEMBL461994 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL488014 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL517591 | — | IC50 | = | 80.8 | nM | 7.09 |
| CHEMBL455140 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL488862 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL454666 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL462167 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL453355 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL462341 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL454665 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL460078 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL453086 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL488702 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL462181 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL453345 | — | IC50 | = | 693.0 | nM | 6.16 |
| CHEMBL488015 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL453346 | — | IC50 | = | 1065.0 | nM | 5.97 |
| CHEMBL488701 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL454907 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1460 | DIDANOSINE | IC50 | = | 5370.0 | nM | 5.27 |