Assay Detail
Binding
CHEMBL1000360
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Inhibition of human Wee1 assessed as polyornithine-tyrosine copolymer phosphorylation
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 7.29 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL472542 | — | — | 1 | 8.22 |
| CHEMBL471163 | — | — | 1 | 8.15 |
| CHEMBL515352 | — | — | 1 | 8.15 |
| CHEMBL471157 | — | — | 1 | 8.10 |
| CHEMBL411662 | — | — | 1 | 8.05 |
| CHEMBL472208 | — | — | 1 | 8.05 |
| CHEMBL459889 | — | — | 1 | 8.05 |
| CHEMBL379975 | — | — | 1 | 7.96 |
| CHEMBL460940 | — | — | 1 | 7.92 |
| CHEMBL511992 | — | — | 1 | 7.89 |
| CHEMBL461116 | — | — | 1 | 7.85 |
| CHEMBL511280 | — | — | 1 | 7.82 |
| CHEMBL471329 | — | — | 1 | 7.80 |
| CHEMBL472209 | — | — | 1 | 7.72 |
| CHEMBL512012 | — | — | 1 | 7.68 |
| CHEMBL512342 | — | — | 1 | 7.68 |
| CHEMBL462170 | — | — | 1 | 7.64 |
| CHEMBL520904 | — | — | 1 | 7.64 |
| CHEMBL513079 | — | — | 1 | 7.62 |
| CHEMBL471156 | — | — | 1 | 7.60 |
| CHEMBL488054 | — | — | 1 | 7.57 |
| CHEMBL213593 | — | — | 1 | 7.55 |
| CHEMBL512341 | — | — | 1 | 7.52 |
| CHEMBL487891 | — | — | 1 | 7.52 |
| CHEMBL520240 | — | — | 1 | 7.48 |
| CHEMBL462011 | — | — | 1 | 7.46 |
| CHEMBL511991 | — | — | 1 | 7.35 |
| CHEMBL486665 | — | — | 1 | 7.27 |
| CHEMBL209388 | — | — | 1 | 7.24 |
| CHEMBL516488 | — | — | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL472542 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL471163 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL515352 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL471157 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL411662 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL472208 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL459889 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL379975 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL460940 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL511992 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL461116 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL511280 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL471329 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL472209 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL512342 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL512012 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL462170 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL520904 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL513079 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL471156 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL488054 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL213593 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL512341 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL487891 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL520240 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL462011 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL511991 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL486665 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL209388 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL516488 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL517744 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL452829 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL215900 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL452078 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL486828 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL529669 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL461134 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL508541 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL486661 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL460079 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL508412 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL529897 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL452079 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL486868 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL214253 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL454908 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL452336 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL519238 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL520071 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL508294 | — | IC50 | = | 120.0 | nM | 6.92 |