Assay Detail
Functional
CHEMBL1000398
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Cytotoxicity against human CCRF-CEM cells expressing reduced folate carrier in absence of thymidine and hypoxanthine
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.37 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452322 | — | — | 1 | 7.22 |
| CHEMBL453090 | — | — | 1 | 7.16 |
| CHEMBL452324 | — | — | 1 | 6.22 |
| CHEMBL453348 | — | — | 1 | 6.22 |
| CHEMBL508910 | — | — | 1 | 6.05 |
| CHEMBL453089 | — | — | 1 | 5.36 |
| CHEMBL452837 | — | — | 1 | - |
| CHEMBL34412 | LOMETREXOL | 2.0 | 1 | - |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | — | 1 | - |
| CHEMBL451818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452322 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL453090 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL452324 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL453348 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL508910 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL453089 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL452837 | — | IC50 | - | — | - | |
| CHEMBL34412 | LOMETREXOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL451818 | — | IC50 | - | — | - |