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Evidence Snapshot

CCRF-CEM

CHEMBL382 CELL-LINE Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T15:35:35Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL382
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CCRF-CEM as ChEMBL target CHEMBL382. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CCRF-CEM
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL382
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why CCRF-CEM matters

As of 2026-09-13

CCRF-CEM is reviewed as CCRF-CEM; the current evidence base includes 75 approved drugs, 53349 compounds, and 3844 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 75 approved drugs, 53349 compounds, and 3844 assays for this target. The dominant activity type is IC50. CHEMBL124364 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL124364 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
75 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why CCRF-CEM matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

53349
Total Compounds
3844
Total Assays
75
Approved Drugs
IC50: 9264.0, KI: 7.0, EC50: 1621.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL124364
 11.0 IC50 —
No preferred name
CHEMBL536102
 10.9 IC50 —
No preferred name
CHEMBL262368
 10.8 IC50 —
No preferred name
CHEMBL331014
 10.8 IC50 —
No preferred name
CHEMBL316640
 10.7 IC50 —

Approved Drugs

Structure Compound First Approval
ARTESUNATE
CHEMBL361497
 2020
MIDOSTAURIN
CHEMBL608533
 2017
CARFILZOMIB
CHEMBL451887
 2009
IXABEPILONE
CHEMBL1201752
 2007
VORINOSTAT
CHEMBL98
 2006
PEMETREXED
CHEMBL225072
 2004
CLOFARABINE
CHEMBL1750
 2004
MYCOPHENOLIC ACID
CHEMBL866
 2004
SIROLIMUS
CHEMBL413
 1999
NEVIRAPINE
CHEMBL57
 1996
GEMCITABINE
CHEMBL888
 1996
SAQUINAVIR
CHEMBL114
 1995
DOCETAXEL
CHEMBL3545252
 1995
STAVUDINE
CHEMBL991
 1994
VINORELBINE
CHEMBL553025
 1994
CLADRIBINE
CHEMBL1619
 1993
ZALCITABINE
CHEMBL853
 1992
PACLITAXEL
CHEMBL428647
 1992
FLUDARABINE PHOSPHATE
CHEMBL1096882
 1991
PODOFILOX
CHEMBL61
 1990
AMSACRINE
CHEMBL43
 1987
MITOXANTRONE
CHEMBL58
 1987
ZIDOVUDINE
CHEMBL129
 1987
ETOPOSIDE
CHEMBL44657
 1983
MITOMYCIN
CHEMBL105
 1981
DOXORUBICIN
CHEMBL53463
 1974
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
 1974
FLOXURIDINE
CHEMBL917
 1970
CYTARABINE
CHEMBL803
 1969
THIOGUANINE
CHEMBL727
 1966
VINBLASTINE
CHEMBL159
 1965
DACTINOMYCIN
CHEMBL1554
 1964
VINCRISTINE
CHEMBL90555
 1963
COLCHICINE
CHEMBL107
 1961
MERCAPTOPURINE ANHYDROUS
CHEMBL1425
 1953
METHOTREXATE
CHEMBL34259
 1953
LEUCOVORIN
CHEMBL1679
 1952
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T15:35:35Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL382