Assay Detail

CHEMBL1000425

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Binding

Inhibition of PDE4 in human lymphocyte

ChEMBL ↗

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Target

Phosphodiesterase 4 (CHEMBL2093863) ↗

Open DB target context

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Phosphodiesterase 4 (CHEMBL2093863) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Phosphodiesterase 4

CHEMBL2093863

Anchored from Assay target.

Protein identity Phosphodiesterase 4

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Phosphodiesterase 4 (CHEMBL2093863) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.

Kodimuthali A, Jabaris SS, Pal M.
J Med Chem (2008) 51 : 5471 -5489
PubMed 18686943 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.30	8.30

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL315815	PYRIDOPYRIDAZINONE	—	1	8.30

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL315815	PYRIDOPYRIDAZINONE	IC50	=	5.012	nM	8.30