Compound Detail
CHEMBL315815
PYRIDOPYRIDAZINONE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL315815 |
| Name | PYRIDOPYRIDAZINONE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DYHGFTMEUMYPOC-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
359.4
MW (Da)
2.81
ALogP
7
HBA
0
HBD
103.8
PSA (Ų)
0.41
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.3
EC50 1 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 8.3 | 8.3 | 5.0 | 2 |
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | EC50 | 6.66 | 6.66 | 220.0 | 1 |
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 6.47 | 6.47 | 340.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | IC50 | = | 5.012 | nM | 8.3 | Inhibition of PDE4 in the cytosol of human neutrophils | 11472205 |
| Phosphodiesterase 4 | IC50 | = | 5.012 | nM | 8.3 | Inhibition of PDE4 in human lymphocyte | 18686943 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | EC50 | = | 220.0 | nM | 6.66 | Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 ... | 21456625 |
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 340.0 | nM | 6.47 | Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemic... | 21456625 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21456625 | 10.1021/jm200070e | 3',5'-cyclic-AMP phosphodiesterase 4A | 2 |
| 11472205 | 10.1021/jm010837k | Phosphodiesterase 4 | 1 |
| 18686943 | 10.1021/jm800582j | Phosphodiesterase 4 | 1 |
Data from ChEMBL 36 via Core Engine