3',5'-cyclic-AMP phosphodiesterase 4A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P27815. Use UniProt P27815 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P27815 as the stable identity anchor, then attach disease evidence before program review.
3',5'-cyclic-AMP phosphodiesterase 4A
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4A, mapped to UniProt P27815. Sequence length is 886 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 3',5'-cyclic-AMP phosphodiesterase 4A as ChEMBL target CHEMBL254, mapped to UniProt P27815. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 3',5'-cyclic-AMP phosphodiesterase 4A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P27815 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3',5'-cyclic-AMP phosphodiesterase 4A |
| UniProt Accession | P27815 |
| Component Type | Protein |
| Sequence Length | 886 aa |
3',5'-cyclic-AMP phosphodiesterase 4A
Review this target as 3',5'-cyclic-AMP phosphodiesterase 4A, mapped to UniProt P27815. Sequence length is 886 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5417689 | 10.5 | IC50 | 0.03162 | Preclinical |
| CHEMBL499477 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL127944 | 10.15 | IC50 | 0.07 | Preclinical |
| CHEMBL3676245 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL377709 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL380321 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL382168 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5892052 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL2402362 | 9.82 | IC50 | 0.15 | Preclinical |
| CHEMBL381681 | 9.8 | IC50 | 0.16 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 86 | 577 | 7.3 |
| cell-based format | 37 | 205 | 7.6 |
| assay format | 11 | 198 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 3 | 7.5 |
| tissue-based format | 1 | 21 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 6 | 6.0 |