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Evidence Snapshot

3',5'-cyclic-AMP phosphodiesterase 4A

CHEMBL254 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:01:59Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL254
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 3',5'-cyclic-AMP phosphodiesterase 4A as ChEMBL target CHEMBL254, mapped to UniProt P27815. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
3',5'-cyclic-AMP phosphodiesterase 4A
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL254
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P27815
3',5'-cyclic-AMP phosphodiesterase 4A
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why 3',5'-cyclic-AMP phosphodiesterase 4A matters

As of 2026-09-13

3',5'-cyclic-AMP phosphodiesterase 4A is reviewed as 3',5'-cyclic-AMP phosphodiesterase 4A (UniProt P27815); the current evidence base includes 6 approved drugs, 1984 compounds, and 143 assays, with lead potency reaching pChEMBL 10.5.

Protein context
3',5'-cyclic-AMP phosphodiesterase 4A

3',5'-cyclic-AMP phosphodiesterase 4A Sequence length is 886 aa.

Review this target as 3',5'-cyclic-AMP phosphodiesterase 4A, mapped to UniProt P27815. Sequence length is 886 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt P27815 Protein
Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 6 approved drugs, 1984 compounds, and 143 assays for this target. The dominant activity type is IC50. CHEMBL5417689 is the current potency anchor at pChEMBL 10.5.

Use CHEMBL5417689 as the tractability anchor when discussing potency (pChEMBL 10.5).

Activity source · ChEMBL 36 via Core Engine
6 approved pChEMBL 10.5
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why 3',5'-cyclic-AMP phosphodiesterase 4A matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P27815, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

1984
Total Compounds
143
Total Assays
6
Approved Drugs
IC50: 1137.0, KI: 110.0, EC50: 20.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL5417689
 10.5 IC50 —
No preferred name
CHEMBL499477
 10.2 IC50 —
No preferred name
CHEMBL127944
 10.2 IC50 —
No preferred name
CHEMBL5892052
 10.0 IC50 —
No preferred name
CHEMBL3676245
 10.0 IC50 —

Approved Drugs

Structure Compound First Approval
CRISABOROLE
CHEMBL484785
 2016
ROFLUMILAST
CHEMBL193240
 2010
IBUDILAST
CHEMBL19449
 1989
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T19:01:59Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL254