Assay Detail
Functional
CHEMBL1000657
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Inhibition of LPS-induced TNFalpha production in human monocytes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Monocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.03 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498222 | — | — | 1 | 7.30 |
| CHEMBL524638 | — | — | 1 | 6.66 |
| CHEMBL495585 | — | — | 1 | 6.57 |
| CHEMBL497883 | — | — | 1 | 6.50 |
| CHEMBL496388 | — | — | 1 | 6.41 |
| CHEMBL496590 | — | — | 1 | 6.16 |
| CHEMBL495866 | — | — | 1 | 5.75 |
| CHEMBL230232 | — | — | 1 | 5.75 |
| CHEMBL496591 | — | — | 1 | 5.41 |
| CHEMBL495867 | — | — | 1 | 5.30 |
| CHEMBL495584 | — | — | 1 | 5.30 |
| CHEMBL526840 | — | — | 1 | 5.30 |
| CHEMBL522217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498222 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL524638 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL495585 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL497883 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL496388 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL496590 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL495866 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL230232 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL496591 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL495867 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL495584 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL526840 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL522217 | — | IC50 | - | — | - |