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Target Snapshot

CHEMBL614076 Target Snapshot

Monocyte · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
306Compounds
134Assays
1Approved Drugs
193.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Monocyte as ChEMBL target CHEMBL614076. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Monocyte
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL614076
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Monocyte still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMonocyte
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMonocyte
UniProt AccessionN/A

Monocyte

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Monocyte.

Review nameMonocyte
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
3
Phase II
1
Phase I
1
Phase 0.5
Assay Mix

Activity Type Distribution

IC50191.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5280103 9.46 IC50 0.35 Preclinical
CHEMBL5282171 8.57 IC50 2.7 Preclinical
CHEMBL2104993 8.54 IC50 2.9 Approved
CHEMBL5274467 8.2 IC50 6.3 Preclinical
CHEMBL5276877 8.19 IC50 6.5 Preclinical
CHEMBL3823499 8.1 IC50 8.0 Preclinical
CHEMBL212968 8.08 IC50 8.3 Preclinical
CHEMBL211775 8.02 IC50 9.6 Preclinical
CHEMBL380030 8.0 IC50 10.0 Preclinical
CHEMBL384795 8.0 IC50 10.0 Preclinical
Distribution

pChEMBL Value Distribution

21
5.0
29
5.5
20
6.0
13
6.5
43
7.0
19
7.5
13
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VORTIOXETINE
CHEMBL2104993
Approved 2013
Properties Compare Identifier
Assay Landscape

Assay Landscape

134
Total Assays
158
Tested Compounds
3
Assay Types
Functional — 120 assays, 158 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 103 156 6.6
assay format 17 2 5.2
ADME — 11 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 0 —
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine