Compound Detail
CHEMBL5276877
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Basic Information
| ChEMBL ID | CHEMBL5276877 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GHERKWFXTMLKFB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
406.6
MW (Da)
5.92
ALogP
3
HBA
0
HBD
6.5
PSA (Ų)
0.52
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Monocyte CHEMBL614076 | IC50 | 8.19 | 8.19 | 6.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Monocyte | IC50 | = | 6.5 | nM | 8.19 | Inhibition of PMA-induced oxidative burst in human monocytes preincubated for 1 ... | 32992247 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32992247 | 10.1016/j.bmc.2020.115760 | Unchecked | 11 |
| 32992247 | 10.1016/j.bmc.2020.115760 | Monocyte | 4 |
| 32992247 | 10.1016/j.bmc.2020.115760 | Prostaglandin G/H synthase 1 | 1 |
| 32992247 | 10.1016/j.bmc.2020.115760 | Prostaglandin G/H synthase 2 | 1 |
Data from ChEMBL 36 via Core Engine